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Academy of Mathematics and Systems Science, CAS
Colloquia & Seminars

Speaker:

Prof. Xiaobo Zhou, Center for Bioinformatics & Systems Biology Chief of Bioinformatics Wake Forest University - School of Medicine

Inviter: 吴凌云
Title:
Big Data Sciences for understanding Genetic and Epigenetic Regulatory Mechanisms
Time & Venue:
2017.4.23 10:00 N813
Abstract:

The explosive growth of biomedical Big Data provides enormous opportunities to revolutionize current clinical practices and biomedical research if the accompanying challenges of heterogeneity in those data can be addressed with novel informatics technologies. Needs of knowledge in translational research and clinical practice and knowledge provided by data-driven informatics technologies are often inconsistent, and new strategies and pipelines are required to bridge this gap. In this talk, I will briefly talk about (1) the TGFBR1-SNP (rs7034462) modulates the affinity of chromatin for FOXA1 and alters TGFBR1 expression, which may lead the development of CRC; (2) Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision; (3) Histone modifications are linked to ESCs fate decision via epigenetic association with the alternative splicing of critical pathways and transcriptional factors in a cell-cycle-dependent manner; and (4) Deep Learning the CRISPR/Cas Code on/off Effects by focusing on the evaluation of on/off-target novel features and integration into the computational CRISPR-based sgRNA Design.

 

 

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